Champions Asante Kotoko open their title defence against city rivals King Faisal at the Baba Yara Stadium when the new Premier League season begins on 23 November.
Kotoko won its 21st league title last term and face a difficult task against Faisal which have been a bogey side.
New coach Maurice Cooreman must double efforts to impress in his first league match and lay their bogey to rest.
Heart of Lions have an uncompromising task away to Berekum Arsenals at the Golden City Park.
Hearts of Oak are favourites in their first outing against newly-promoted Great Mirren at the El-Wak Park.
Liberty Professionals engage newly-installed Bechem Chelsea at the Dansoman Karl Reindorff Park.
Sekondi Hasaacas host Wa All Stars at the Essipong Stadium and AshantiGold tackle Real Tamale United at the Len Clay Stadium.
Kessben Football Club have another new entrant to deal with in Sekondi Eleven Wise at Abrankese.
Tema Youth start their league campaign away to All Blacks at the Cape-Coast Robert Mensah Stadium.
