Great Olympics face a difficult task to register their first win against leaders AshantiGold at the Ohene Djan Stadium on Sunday.
Olympics are finding life tough in the top flight after earning a return this term having already suffered two straight loses.
AshantiGold risk losing their position at the top with a defeat after failing to beat rivals Asante Kotoko at home last Sunday.
Liberty Professionals, second on the league log, must continue with the momentum on a difficult turf in Wa against All Stars.
Ex-international Maxwell Konadu takes charge of his first game of All Stars who need points to pull away from the second-bottom spot.
Sekondi Eleven Wise's trip to Kessben is likely to be enveloped with defeat after the latter fell to Hearts last Sunday.
Newly installed Aduana Stars are at the Dormaa Park against Heart of Lions who have been handed an opportunity to reverse their bad away record.
King Faisal face a tricky duel at the Len Clay Sports Stadium against New Edubiase United side at the Len Clay.
Sekondi Hasaacas host champions Hearts of Oak at the Essipong Stadium; Chelsea of Bechem want to take advantage of playing at home against Real Tamale United.
Asante Kotoko entertain Berekum Arsenals at the Baba Yara Stadium in the late kick-off with a win much needed for coach Paa Kwesi Fabin to win the hearts of the home fans.
